Actively Trying Fertility Lubricant Best Lube for Postpartum Sex Postpartum Together Vaginal Lubrication: Vaginal Dryness, Vaginal Health, and More Can your lube affect your chances of getting pregnant? Yes some lubricants can make it harder for sperm to reach the egg. Look for sperm safe or fertility friendly formulas that mimic your Condoms protect against unplanned pregnancy and most sexually transmitted infections, including HIV, gonorrhoea, chlamydia and syphilis. Use only water or silicone based lubricant with a condom during vaginal and particularly anal sex